Inducing Oncoprotein Degradation to Improve Targeted Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Inducing Oncoprotein Degradation to Improve Targeted Cancer Therapy1
Over the past decade, inhibition of the kinase activities of oncogenic proteins using small molecules and antibodies has been a mainstay of our anticancer drug development effort, resulting in several Food and Drug Administration-approved cancer therapies. The clinical effectiveness of kinase-targeted agents has been inconsistent, mostly because of the development of resistance. The expression ...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2015
ISSN: 1476-5586
DOI: 10.1016/j.neo.2015.08.008